Research & Evidence Library : Obesity studies, clinical trials and evidence

Welcome to the All About Obesity Research & Evidence Library, a place to explore the evidence behind obesity, from clinical trials in the UK and international research studies, to case studies, real-world evidence and emerging treatment data.

At All About Obesity, we know how difficult it can be to navigate the sheer volume of information, opinion and, at times, misinformation surrounding obesity. Our aim is to make evidence easier to access and understand by bringing together trusted research in one place, helping people living with obesity, healthcare professionals, researchers, policymakers and advocates find reliable information more easily.

We hope this library helps support a better understanding of obesity as a complex, chronic disease, and makes it easier to access evidence that can inform care, conversations, policy and practice.

Please note:  The information provided in this library is for educational purposes only and should not replace medical advice, diagnosis or treatment. If you have questions about your own health, please speak to a qualified healthcare professional.

Author Top Level Topic Link
Sarah Le Brocq The reality of living with obesity View publication
Sarah Le Brocq Advancing person-centered care in the new era of obesity treatment View publication
Sarah Le Brocq The real-life experiences of people living with overweight and obesity: a psychosocial perspective View publication
Sarah Le Brocq The importance of language in engagement between health-care professionals and people living with obesity: a joint consensus statement View publication
Sarah Le Brocq Outcomes of the first global multidisciplinary consensus meeting including persons living with obesity to standardize patient-reported outcome measurement in obesity treatment research View publication
Sarah Le Brocq The implications of defining obesity as a disease: a report from the association for the study of obesity 2021 annual conference View publication
Sarah Le Brocq Compassionate care in obesity management: reclaiming humanity in health care View publication
Sarah Le Brocq In response to “normalization of plus size and the danger of unseen overweight and obesity in england” View publication
Sarah Le Brocq Ten top tips for the management of GLP-1 receptor agonists in adults within primary care View publication
Sarah Le Brocq Commissioning of tier 3 obesity services by integrated care boards in England: an analysis of responses to freedom of information requests View publication
Sarah Le Brocq Variation in the commissioning of semaglutide for the treatment of obesity and overweight across England: results of three freedom of information-based mapping exercises across the 42 integrated care boards of England View publication
Sarah Le Brocq Concerns regarding “association between intelligence quotient and obesity in England” and unjustifiable harm to people in bigger bodies View publication
Sarah Le Brocq Obesity and COVID-19: a call for action from people living with obesity View publication
Sarah Le Brocq Changing the global obesity narrative to recognize and reduce weight stigma: a position statement from the World Obesity Federation View publication
Dr Giles Yeo Metabolism in the spotlight: Dr. Giles Yeo on the impact and challenges of science communication View publication
Dr Giles Yeo The genetics of obesity: from discovery to biology View publication
Dr Giles Yeo Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation View publication
Dr Giles Yeo Systemic proteome adaptions to 7-day complete caloric restriction in humans View publication
Dr Giles Yeo The melanocortin pathway and energy homeostasis: from discovery to obesity therapy View publication
Dr Giles Yeo Hypomap – a unified single-cell gene expression atlas of the murine hypothalamus View publication
Dr Giles Yeo A comprehensive spatio-cellular map of the human hypothalamus View publication
Dr Giles Yeo Glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus regulate food intake View publication
Dr Giles Yeo GDF15 linked to maternal risk of nausea and vomiting during pregnancy View publication
Dr Giles Yeo Fetal manipulation of maternal metabolism is a critical function of the imprinted IGF2 gene View publication
Dr Giles Yeo Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans View publication
Dr Giles Yeo GDF15 mediates the effects of metformin on body weight and energy balance View publication
Dr Giles Yeo Breaking our daily “ultra-processed” bread View publication
Dr Giles Yeo POMC neuronal heterogeneity in energy balance and beyond: an integrated view View publication
Dr Giles Yeo Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence View publication
Dr Giles Yeo The imprinted IGF2-IGF2R axis is critical for matching placental microvasculature expansion to fetal growth View publication
Dr Giles Yeo Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15 View publication
Dr Giles Yeo A rare human variant that disrupts GPR10 signalling causes weight gain in mice View publication
Dr Giles Yeo A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing View publication
Dr Giles Yeo Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease View publication
Dr Giles Yeo A brainstem to hypothalamic arcuate nucleus GABAergic circuit drives feeding View publication
Dr Giles Yeo Author correction: a comprehensive spatio-cellular map of the human hypothalamus View publication
Dr Giles Yeo The metabolic and cardiovascular effects of amphetamine are partially mediated by the central melanocortin system View publication
Dr Giles Yeo Neurochemical characterization of brainstem pro-opiomelanocortin cells View publication
Dr Giles Yeo Finding genes that control body weight View publication
Dr Giles Yeo Biallelic mutations in P4HTM cause syndromic obesity View publication
Dr Giles Yeo Are GLP-1R agonists the long-sought-after panacea for obesity? View publication
Dr Giles Yeo The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling View publication
Dr Giles Yeo Metabolism in the spotlight: Dr. Giles Yeo on the impact and challenges of science communication View publication
Dr Giles Yeo Genetics of obesity: can an old dog teach us new tricks? View publication
Dr Giles Yeo DAX1 modulates ERα-dependent hypothalamic estrogen sensing in female mice View publication
Dr Giles Yeo Is calorie labelling on menus the solution to obesity? View publication
Dr Giles Yeo High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor View publication
Dr Giles Yeo Functional heterogeneity of POMC neurons relies on mTORC1 signaling View publication
Dr Giles Yeo Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing View publication
Dr Giles Yeo GDF15 and energy balance: homing in on a mechanism View publication
Dr Giles Yeo Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort View publication
Dr Giles Yeo The importance of science communication surrounding weight-loss drugs View publication
Dr Giles Yeo Low resting metabolic rate and increased hunger due to β-MSH and β-endorphin deletion in a canine model View publication
Dr Giles Yeo Important role of the GLP-1 axis for glucose homeostasis after bariatric surgery View publication
Dr Giles Yeo Improve 2022 international meeting on pathway-related obesity: vision of excellence View publication
Dr Giles Yeo Chronic activation of γ2 AMPK induces obesity and reduces β cell function View publication
Dr Giles Yeo From identity to function: unveiling the cellular complexity of hypothalamic feeding circuits View publication
Dr Giles Yeo Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment View publication
Dr Giles Yeo Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression View publication
Dr Giles Yeo The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling View publication
Dr Giles Yeo Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity View publication
Dr Giles Yeo Fasting pancreatic polypeptide predicts incident microvascular and macrovascular complications of type 2 diabetes: an observational study View publication
Dr Giles Yeo Obesity-associated gene TMEM18 has a role in the central control of appetite and body weight regulation View publication
Dr Giles Yeo Publisher correction: GDF15 mediates the effects of metformin on body weight and energy balance View publication
Dr Giles Yeo Adult-onset hyperinsulinaemic hypoglycaemia in clinical practice: diagnosis, aetiology and management View publication
Dr Giles Yeo Impaired prohormone processing: a grand unified theory for features of Prader-Willi syndrome? View publication
Dr Giles Yeo 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats View publication
Dr Giles Yeo A multicomponent screen for feeding behaviour and nutritional status in Drosophila to interrogate mammalian appetite-related genes View publication
Dr Giles Yeo High coexpression of the ghrelin and LEAP2 receptor GHSR with pancreatic polypeptide in mouse and human islets View publication
Dr Giles Yeo Thyroid hormone receptor beta in the ventromedial hypothalamus is essential for the physiological regulation of food intake and body weight View publication
Dr Giles Yeo Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity View publication
Dr Giles Yeo Contributions of function-altering variants in genes implicated in pubertal timing and body mass for self-limited delayed puberty View publication
Dr Giles Yeo Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profiling View publication
Dr Giles Yeo Maternal obesity in pregnancy developmentally programs adipose tissue inflammation in young, lean male mice offspring View publication
Dr Giles Yeo Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet View publication
Dr Giles Yeo A deletion in the canine POMC gene is associated with weight and appetite in obesity-prone Labrador retriever dogs View publication
Dr Giles Yeo Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets View publication
Dr Giles Yeo The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation View publication
Dr. Stuart Flint Joint international consensus statement for ending stigma of obesity View publication
Dr. Stuart Flint Editorial: the implications of weight bias internalization View publication
Dr. Stuart Flint Pervasiveness, impact and implications of weight stigma View publication
Dr. Stuart Flint The weight of expectation – how weight stigma is impacting dietetic practice View publication
Dr. Stuart Flint Rethinking the label anti-obesity medication View publication
Dr. Stuart Flint A core set of patient-reported outcome measures to measure quality of life in obesity treatment research View publication
Dr. Stuart Flint Addressing weight stigma and communicating with patients View publication
Dr. Stuart Flint Outcomes of the first global multidisciplinary consensus meeting including persons living with obesity to standardize patient-reported outcome measurement in obesity treatment research View publication
Dr. Stuart Flint Disability discrimination and obesity: the big questions? View publication
Dr. Stuart Flint Editorial: obesity stigma in healthcare: impacts on policy, practice, and patients View publication
Dr. Stuart Flint Error in NHS England’s BMI calculator and daily calorie recommendations View publication
Dr. Stuart Flint Knowledge gaps and weight stigma shape attitudes toward obesity View publication
Dr. Stuart Flint Core set of patient-reported outcome measures for measuring quality of life in clinical obesity care View publication
Dr. Stuart Flint Obesity stigmatisation from obesity researchers View publication
Dr. Stuart Flint Medications for obesity as preventatives: a public and patient safety issue View publication
Dr. Stuart Flint Changing frames of obesity in the UK press 2008-2017 View publication
Dr. Stuart Flint Time to end weight stigma in healthcare View publication
Dr. Stuart Flint The impact of living through COVID-19 pandemic on mental health, food insecurity, loneliness and health behaviours in people with obesity View publication
Dr. Stuart Flint The NHS long-term plan: a comparison of the narrative used for cancer and obesity View publication
Dr. Stuart Flint Perceived weight-related stigma, loneliness, and mental wellbeing during COVID-19 in people with obesity: a cross-sectional study from ten European countries View publication
Dr. Stuart Flint Weight stigma in Australia: a public health call to action View publication
Dr. Stuart Flint UK dietitians’ attitudes and experiences of formula very low- and low-energy diets in clinical practice View publication
Dr. Stuart Flint My words would have more weight: exploring weight stigma in UK dietetic practice and dietitian’s lived experiences of weight stigma View publication
Dr. Stuart Flint The real-life experiences of people living with overweight and obesity: a psychosocial perspective View publication
Dr. Stuart Flint Effect of health-care professionals’ weight status on patient satisfaction and recalled advice: a prospective cohort study View publication
Dr. Stuart Flint Explicit and implicit weight bias among health care students: a cross-sectional study of 39 Australian universities View publication
Dr. Stuart Flint Weight stigma in frequent exercisers: overt, demeaning and condescending View publication
Dr. Stuart Flint The association between childhood trauma and overweight and obesity in young adults: the mediating role of food addiction View publication
Dr. Stuart Flint Disparate healthcare experiences of people living with overweight or obesity in England View publication
Dr. Stuart Flint Portrayal and social response to the new era of medications for obesity View publication
Dr. Stuart Flint Demographic, socioeconomic and life-course risk factors for internalized weight stigma in adulthood: evidence from an English birth cohort study View publication
Dr. Stuart Flint A mixed-method analysis of the #sugartax debate on Twitter View publication
Dr. Stuart Flint Efficacy of interventions aimed at reducing explicit and implicit weight bias in healthcare students: a systematic review and meta-analysis View publication
Dr. Stuart Flint COVID-19 and obesity – lack of clarity, guidance, and implications for care View publication
Dr. Stuart Flint Delivery of the national child measurement programme in England View publication
Dr. Stuart Flint Health is complex, discrimination is unacceptable: call for government legislation View publication
Dr. Stuart Flint Weight bias internalization: the maladaptive effects of moral condemnation on intrinsic motivation View publication
Dr. Stuart Flint Weight stigma and discrimination: a call to the media View publication
Dr. Stuart Flint Menu labelling and food choice in obese adults: a feasibility study View publication
Dr. Stuart Flint Lessons learned from the lived experiences of people living with obesity during the first COVID-19 lockdown in the United Kingdom View publication
Dr. Stuart Flint 3D surface-imaging for volumetric measurement in people with obesity View publication
Dr. Stuart Flint A call for increased involvement of people with obesity and neurodiversity in policy, research, and practice View publication
Dr. Stuart Flint Misconceptions about obesity and weight stigma in Brazilian healthcare professionals View publication
Dr. Stuart Flint Stigmatizing attitudes and misconceptions about obesity among Spanish healthcare professionals View publication
Dr. Stuart Flint In response to “normalization of plus size and the danger of unseen overweight and obesity in England” View publication
Dr. Stuart Flint The impact of workplace health promotion programs emphasizing individual responsibility on weight stigma and discrimination View publication
Dr. Stuart Flint Seven-year itch: the UK government’s difficult relationship with the food and drink industry since Healthy Lives, Healthy People: a call to action on obesity in England (2011) View publication
Dr. Stuart Flint Weight stigma in Latin America and the Caribbean: a call to action View publication
Dr. Stuart Flint A randomised controlled trial of a lived experience and education-based weight bias intervention for Australian healthcare students View publication
Dr. Stuart Flint Is personality associated with the lived experience of the NHS England low calorie diet programme: a pilot study View publication
Dr. Stuart Flint Mindfulness-based eating in obesity and anxiety: a randomized controlled trial and feasibility assessment View publication
Dr. Stuart Flint Obesity discrimination in the recruitment process: “you’re not hired!” View publication
Dr. Stuart Flint Negative impact of the first COVID-19 lockdown upon health-related behaviours and psychological wellbeing in people living with severe and complex obesity in the UK View publication
Dr. Stuart Flint Preferences and emotional response to weight-related terminology used by healthcare professionals to describe body weight in people living with overweight and obesity View publication
Dr. Stuart Flint UK adults’ implicit and explicit attitudes towards obesity: a cross-sectional study View publication
Dr. Stuart Flint Stigmatizing media portrayal of obesity during the coronavirus (COVID-19) pandemic View publication
Dr. Stuart Flint Variation in the commissioning of specialist weight management services and bariatric surgery across England: results of a freedom of information-based mapping exercise across the 42 integrated care systems of England View publication
Dr. Stuart Flint A randomised feasibility study assessing acute physiological responses to weight stigma in women living with obesity View publication
Dr. Stuart Flint Exploring responses to body weight criticism: defensive avoidance when weight is seen as controllable View publication
Dr. Stuart Flint Attitudes, stigma and knowledge on obesity in Mexico: a national cross-sectional survey of the general population and healthcare professionals living with or without obesity View publication
Dr. Stuart Flint Variation in the commissioning of semaglutide for the treatment of obesity and overweight across England: results of three freedom of information-based mapping exercises across the 42 integrated care boards of England View publication
Dr. Stuart Flint Evaluation of the NHS England low-calorie diet implementation pilot: a coproduced mixed-method study View publication
Dr. Stuart Flint Gotta catch ’em all: impact of Pokémon Go on physical activity, sitting time, and perceptions of physical activity and health at baseline and three-month follow-up View publication
Dr. Stuart Flint Counter-conditioning as an intervention to modify anti-fat attitudes View publication
Dr. Stuart Flint Sheffield Hallam staff wellness service: four-year follow-up of the impact on health indicators View publication
Dr. Stuart Flint Infecting academic conferences: brands linked to ill health View publication
Dr. Stuart Flint Are we selling our souls? Novel aspects of the presence in academic conferences of brands linked to ill health View publication
Dr. Stuart Flint Examining consumers’ adoption of wearable healthcare technology: the role of health attributes View publication
Dr. Stuart Flint Public transport and the promotion of unhealthy food and drink View publication
Dr. Stuart Flint Smart technology for healthcare: exploring the antecedents of adoption intention of healthcare wearable technology View publication
Dr. Stuart Flint An exploration of the portrayal of the UK soft drinks industry levy in UK national newspapers View publication

Last updated: August  2026

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